Selective release of newly synthesized cardiac norepinephrine induced by angiotensin II |
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| Authors: | C Chevillard N Duchene J M Alexander |
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| Affiliation: | 1. Department of Cardiac Surgery, Reference and Translation Center for Cardiac Stem Cell Therapy (RTC), University Medical Center Rostock, 18057 Rostock, Germany;2. Faculty of Interdisciplinary Research, Department Life, Light & Matter, University Rostock, 18059 Rostock, Germany;1. Department of Clinical Pharmacology, Medical University of Bialystok, Waszyngtona 15a, 15274 Bialystok, Poland;2. Department of Clinical Molecular Biology, Medical University of Bialystok, Poland;3. Department of Psychiatry, Medical University of Bialystok, Poland |
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| Abstract: | The releasing action of angiotensin II (AngII) and of amphetamine on endogenous norepinephrine (NE), 3H-NE-labeled pools, and 3H-NE newly synthesized from 3H-dopamine (3H-DA) was investigated in rat cardiac slices.In contrast to amphetamine, AngII did not affect endogenous NE or 3H-NE stored for a long period. Both drugs induced release of 3H-NE newly synthesized from 3H-DA.Consequent to this utilization, AngII enhanced 3H-NE synthesis from 3H-DA, while amphetamine decreased it. Increase in synthesis was related to increase in tissue 3H-DA accumulation, and, decrease by amphetamine, to its reduction. |
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