Alzheimer型痴呆的CT与MRI研究

目的验证海马萎缩在Ａｌｚｈｅｉｍｅｒ型痴呆（ＤＡＴ）中作为一种预测标志的价值，为临床提供辅助诊断方法。材料与方法选３０名受检者全部通过简易精神状态检查（ｍｉｎｉ－ｍｅｎｔａｌｓｔａｔｅｅｘ－ａｍｉｎａｔｉｏｎ，ＭＭＳＥ），ＣＴ扫描观察海马周围裂的变化，并测量海马内侧的脑脊液池（ＨＣＳＦ），即测量环池内侧边到颞叶内侧边之间的距离。选其中１３名行ＭＲＩ扫描测量海马结构（ＨＦ）体积。结果在正常人中区分Ａｌｚｈｅｉｍｅｒ型痴呆病人最敏感的测量是ＭＭＳＥ，最特异性的测量是ＨＣＳＦ。ＨＦ体积与ＭＭＳＥ在正常组中无相关性，而在ＤＡＴ组中有显著的相关关系。结论我们的研究表明：海马周围裂的扩大及海马体积缩小对临床诊断ＤＡＴ是一个有用的放射学标志

The Role of CT and MRI in the assessment of dementia of Alzheimer type

Purpose To test the predictive value of atrophy of hippocampal formation(HF) in detecting dementia of Alzheimer type(DAT) patients with CT and MRI. Materials and methods A total of 30 subjects (13 DAT patients and 17 normal volunteers)were studied with CT. The MR examinations were performed in 13 subjects(8 DAT and 5 normal). The width of choroidal fissure/hippocampal fissure on CT and MR imaging was measured to assess the HF volume. Results MMSE sensitivity exceeded that of choroidal fissure/hippocampal fissure in DAT patients and the specificity of choroidal fissure/hippocampal fissure was superior to that of MMSE in normal volunteers. A significant correlation ( P <0.05)between MMSE score and HF volume was observed in all DAT patients. Conclusion Dilatation of choroidal fissure/ hippocampal fissure and reduction of HF volume were a useful radiologic marker for the diagnosis of DAT.