Granulomatous mycosis fungoides with small intestinal involvement and a fatal outcome |
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Authors: | Chen,Tanaka,& Miyakawa |
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Affiliation: | Division of Dermatology, Ogikubo Hospital, 3-1-24 Imagawa, Suginami-ku, Tokyo 167, Japan,;Department of Dermatology, Keio University School of Medicine, Tokyo, Japan,;Division of Dermatology, Kawasaki City Hospital, Kawasaki City, Japan |
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Abstract: | We report a case of granulomatous mycosis fungoides that progressed into fatal gastrointestinal involvement 4 years after the onset of skin lesions, despite improvement of the skin lesions in response to a combination of PUVA and systemic interferon-gamma therapy. Histological examination showed Pautrier's microabscesses with granuloma annulare-like features and sarcoidal granuloma formation in the plaque stage, proliferation of blast-transformed atypical lymphocytes with persistent granuloma formation in the tumour stage, and metastatic lesions. A literature review of granulomatous mycosis fungoides revealed that 11 of the 24 reported cases died of the disease, and like our case, seven died within 5 years. We suggest that mycosis fungoides with granulomatous reactions does not indicate a favourable prognosis. |
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