Simultaneous onset of type 1 diabetes in monozygotic twins younger than 1 year |
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Authors: | Noriko Uchida Yoshiro Amano Yohei Akazawa Shinichi Nakamura Isaki Minami Kazuhiko Washizawa Yasunobu Wakabayashi Kozo Yasui |
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Institution: | (1) Department of Pediatrics, Nagano Red Cross Hospital, Wakasato 5-22-1, Nagano 380-8582, Japan |
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Abstract: | This report describes type 1 insulin deficient diabetes mellitus (IDDM) arising in identical twins aged under one year. One
twin presented with symptoms and was diagnosed with type 1 IDDM; the diagnosis of type 1 IDDM was simultaneously made in the
second twin without clinical symptoms. Both twins were positive for anti-GAD (glutamic acid decarboxylase) antibody at first,
and then positive for islet cell antibodies. Interestingly, the twins have four susceptible HLA DR and DQ genes together that
are usually recognized separately in IDDM patients in Japan. |
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Keywords: | Type 1 diabetes Monozygotic twins Etiology Virus infection |
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