A Phase II Study of Nimustine Hydrochloride,Cisplatin, and Etoposide Combination Chemotherapy for Supratentorial Malignant Gliomas |
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Authors: | Beppu Takaaki Yoshida Yuki Arai Hiroshi Wada Tsukasa Suzuki Michiyasu Ogawa Akira Hakozaki Seiji Kubo Naohiko |
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Affiliation: | (1) Department of Neurosurgery, Iwate Medical University, Morioka, Japan;(2) Department of Neurosurgery, Morioka Redcross Hospital, Morioka, Japan |
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Abstract: | Twenty-eight patients who were previously treated by aggressive surgery and radiation and were diagnosed with supratentorial malignant gliomas received a combination of nimustine hydrochloride; 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU), cisplatin and etoposide (ACE therapy) as primary treatment. Cisplatin and etoposide were given at doses of 20 and 60mg/m2/day for 5 days, respectively, ACNU doses 80mg/m2/day on the first day. Treatment was repeated at 4-week intervals for up to 3 cycles. Seventeen patients (60.7%) complained of nausea. Grade 3 or 4 hematological toxicity occurred in 11 patients (39.3%), and grade 3 or 4 renal toxicity occurred in 2 patients. The percentage of patients who showed complete or partial response was 28.6% (8/28). The median time of tumor progression was 40 weeks, and the median survival time was 146 weeks. There were some long-surviving patients who may have benefited from ACE combination. This study demonstrated the effects of ACE combination in patients with supratentorial malignant gliomas. |
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Keywords: | phase II study ACNU cisplatin etoposide gliomas |
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