| 胃癌的雌孕激素受体状况与预后关系的临床探讨 |
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| 引用本文： | 钱志英 江伟. 胃癌的雌孕激素受体状况与预后关系的临床探讨[J]. 肿瘤研究与临床, 1999, 11(4): 232-233 |
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| 作者姓名： | 钱志英 江伟 |
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| 作者单位： | 江苏省肿瘤医院 |
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| 摘 要： | 目的探讨胃癌的雌、孕激素受体状况与预后关系。方法对３４例胃癌根治术后的标本以免疫组化（ＡＢＣ法）作ＥＲ、ＰＲ测定，并作５ａ随访。结果ＥＲ、ＰＲ阳性率皆为４１．２％（１４／３４）。高分化胃癌ＥＲ、ＰＲ阳性率（２６．９％）明显低于分化差的胃癌组（８７．５％）。随访５ａ，存活者中原来标记的ＥＲ、ＰＲ阳性率较低，仅为２０％。结论胃癌根治术后除辅以化疗外，ＥＲ、ＰＲ阳性者加内分泌治疗可能会提高５ａ生存率。
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| 关 键 词： | 雌激素受体（ER） 孕激素受体（PR） 免疫组化 胃癌 |
CLINICAL EXPLORATION ON THE RELATIONSHIP BETWEEN ESTROGEN AND PROGESTERONE RECEPTORS AND PROGNOSIS OF GASTRIC CANCER |
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| Qian Zhiying,Jiang Wei,Li Li,et al Jiangsu Cancer Hospital. CLINICAL EXPLORATION ON THE RELATIONSHIP BETWEEN ESTROGEN AND PROGESTERONE RECEPTORS AND PROGNOSIS OF GASTRIC CANCER[J]. Cancer Research and Clinic, 1999, 11(4): 232-233 |
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| Authors: | Qian Zhiying Jiang Wei Li Li et al Jiangsu Cancer Hospital |
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| Abstract: | Objective To explore the relationship between estrogen receptor(ER) and progesteron recepter (PR) and prognosis of gastric cancer. Methods 34 gastric samples of gastrectomy were analyzed by immunohistochemistry (ABC method) on ER and PR.The five year follow up was done.Results The positive rate of ER and PR were both 41.2%(14/34), but that was significantly lower in well differentiated group(26.9%) than in poorly differentiated group (87.5%).In the five year follow up,the positive rate of ER and PR in the survivors was only 20%.Conclusion After radical gastrectomy,except for adjuvant chemotherapy, endocrine therapy may be helpful in improving the five year survival rate of ER and PR positive patients. |
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| Keywords: | Estrogen receptor (ER) Progestorone receptor (PR) Immunohistochemistry Gastric cancer |
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