骨保护素在急性冠状动脉综合征中的应用价值

骨保护素(OPG)是由成骨细胞分泌的一种无跨膜结构的可溶性糖蛋白,可影响血管钙化和动脉硬化的过程,是动脉粥样硬化进程及心血管病病死率的独立危险因子。OPG与急性冠状动脉综合征(ACS)具有相关性,在急性心肌梗死和不稳定型心绞痛患者的血清中均发现较高水平的OPG表达。虽然这一特点的具体机制尚不明确,但OPG在ACS临床应用中的价值不可忽视。

Use of Osteoprotegerin in Acute Coronary Syndrome

OPG(osteoprotegerin) is a soluble glycoprotein secreted by osteoblasts in a structure of a nontransmembrane protein,which may affect the process of vascular calcification and atherosclerosis and the process of atherosclerosis,as an independent risk factor of cardiovascular disease mortality.Studies have shown that the association of OPG with ACS in patients with acute myocardial infarction and unstable angina have been found in sera of patients with high levels of OPG expression.Although the characteristics of the specific mechanisms are unclear,the clinical application of OPG in the ACS cannot be ignored for its value.