Concomitant adenocarcinoma and colonic non-Hodgkin's lymphoma in a patient with ulcerative colitis: A case report and molecular analysis |
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Authors: | Takashi Nishigami Tatsuki R. Kataoka Ikuko Torii Ayuko Sato Kazuo Tamura Hiroshi Hirano Nobuyuki Hida Hiroki Ikeuchi Tohru Tsujimura |
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Affiliation: | 1. Department of Pathology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan;2. Department of Life Science, School of Science and Engineering, Kinki University, Higashi-Osaka, Osaka, Japan;3. Department of Pathology, Nippon Steel Hirohata Hospital, Himeji, Hyogo, Japan;4. Endoscopic Center, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan;5. Department of Lower Gastroenterology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan |
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Abstract: | Ulcerative colitis (UC) complicated by colonic lymphoma is rare, although UC is often accompanied by adenocarcinoma of the colon. A concurrent existence of adenocarcinoma and lymphoma in a patient with UC is extremely rare, and has not yet been analyzed at the molecular level. We report a 64-year-old female patient with concomitant adenocarcinoma and diffuse large B-cell lymphoma (DLBCL) in the colon of UC. The genetic changes in these two neoplasms were analyzed. The colon adenocarcinomas had a mutation in MSH6 gene, DNA methylation in CDKN2A gene, and increased microsatellite instability (MSI), although these genetic changes were not recognized in either DLBCL or non-neoplastic UC mucosa. The DLBCL was diagnosed as primary colonic lymphoma, and confirmed Epstein-Barr virus (EBV) infection. The adenocarcinomas and the non-neoplastic UC mucosa were EBV-negative. Our case presented here clearly shows that the development of adenocarcinoma and lymphoma in the colon with UC was caused by individual mechanisms. |
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Keywords: | Ulcerative colitis Adenocarcinoma Malignant lymphoma EB virus Rheumatoid arthritis |
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