Liposarcomatous differentiation in malignant peripheral nerve sheath tumor: A case report |
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| Authors: | Roberto Tirabosco,Malcolm Galloway,Robert Bradford,Paul O&rsquo Donnell,Adrienne M. Flanagan |
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| Affiliation: | 1. Department of Histopathology, Institute of Orthopaedics and Musculoskeletal Science, The Royal National Orthopaedic Hospital, Brockley Hill – Stanmore, HA7 4LP Middlesex, UK;2. Department of Histopathology, The Royal Free Hospital, London, UK;3. Department of Neurosurgery, The Royal Free Hospital, London, UK;4. Department of Radiology, The Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK;5. The Institute of Orthopaedics and Musculoskeletal Science, University College London, London, UK |
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| Abstract: | A 63-year-old man was admitted at the emergency department in an acute confusional state, and a computerized tomography scan (CT) revealed hydrocephalus. Despite the rapid introduction of a ventriculo-peritoneal shunt, the patient died soon thereafter. At the post-mortem examination, a large solid mass was found to be firmly attached to a nerve root at the L1–L2 level. Microscopically, the tumor showed the classical features of a malignant peripheral nerve sheath tumor (MPNST) with rhabdomyoblastic differentiation. In addition, there were randomly distributed lobules of well-differentiated adipose tissue with unequivocal atypical nuclei. The diagnosis of MPNST with rhabdomyoblastic and lipoblastic differentiation was made. We are not aware of previously reported lipoblastic differentiation in MPNST. Herein, we present details of the case. |
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| Keywords: | Malignant peripheral nerve sheath tumor Divergent differentiation Lipoblastic differentiation |
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