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Clinical correlates of elevated serum concentrations of cytokines and autoantibodies in patients with spinal cord injury
Authors:Davies Andrew L  Hayes Keith C  Dekaban Gregory A
Institution:a Graduate Program in Neuroscience, London, ON, Canada
b Department of Physical Medicine & Rehabilitation, London, ON, Canada
c Lawson Health Research Institute, London, ON, Canada
d Department of Microbiology and Immunology, London, ON, Canada
e Biotherapeutics Research Group, Robarts Research Institute, London, ON, Canada
f University of Western Ontario, London, ON, Canada.
Abstract:Davies AL, Hayes KC, Dekaban GA. Clinical correlates of elevated serum concentrations of cytokines and autoantibodies in patients with spinal cord injury.

Objective

To determine the serum cytokine profiles of patients with spinal cord injury (SCI) and varying clinical presentations relative to healthy, able-bodied, age-matched control subjects.

Design

Cross-sectional study.

Setting

Clinical research unit.

Participants

People with SCI (N=56) and different clinical presentations, and healthy, able-bodied, age-matched control subjects (N=35).

Interventions

Not applicable.

Main Outcome Measures

Serum levels of the proinflammatory cytokines interleukin (IL) 1β, IL-6, tumor necrosis factor alpha (TNF-α), the anti-inflammatory cytokines IL-4 and IL-10, the regulatory cytokine IL-2, the IL-1 receptor antagonist (IL-1RA), and autoantibodies against myelin-associated glycoprotein and GM1 ganglioside (anti-GM1) immunoglobulin (IgG and IgM), as determined by enzyme-linked immunosorbent assay. The relationship between elevated serum cytokine levels and clinical variables was also studied.

Results

SCI subjects exhibited serum concentrations of IL-6, TNF-α, IL-1RA, and anti-GM1 (IgG) that were greater (P<.05) than control group values. Elevated cytokine concentrations were not associated with high white blood cell counts, level of injury, or American Spinal Injury Association classification; they were evident in SCI subjects who were asymptomatic for medical complications, but were further elevated in subjects with pain, urinary tract infection (UTI), and pressure ulcers.

Conclusions

Elevated levels of circulating proinflammatory cytokines and autoantibodies are present in the serum of SCI subjects without medical complications, and are further elevated in SCI subjects with neuropathic pain, UTI, or pressure ulcers, relative to healthy, able-bodied control subjects. These findings may be indicative of a protective autoimmunity, simply a consequence of occult or evident infection, or evidence of cytokine dysregulation that may contribute to an immune-mediated impairment of axonal conduction.
Keywords:Autoantibodies  Cytokines  Gangliosides  Interleukin-1 receptors  Interleukin-6  Myelin-associated glycoprotein  Pressure ulcer  Rehabilitation  Spinal cord injuries  Tumor necrosis factor  Urinary tract infections
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