132名低龄儿童应用甲型肝炎灭活疫苗初次免疫效果观察

目的 为了评价孩尔来福甲型肝炎灭活疫苗在本地区低龄儿童应用中的初次免疫效果。方法 对初次应用甲型肝炎灭活疫苗免疫的2～6岁甲肝易感儿童132人随机分成4组，观察初次免疫后局部反应和全身反应，检测免疫后1、3、6．7个月的血清抗甲肝病毒抗体（抗-HAV）阳转率和滴度（GUT）。结果 显示孩尔来福甲型肝炎无局部及全身反应，初次免疫后1、3、6、7个月抗-HAV阳转率分别为100％、97．83％、100％、100％，抗-HAV滴度分别为744．35mIU／ml、524．41mIU／ml、354．34mIU／ml、333．13mIU／ml。结论 各组之间差异无显著的统计学意义。表明孩尔来福甲型肝炎灭活疫苗在低龄儿童中应用是非常安全的；并且具有良好的免疫效果：儿童型每剂含病毒抗原250U，适用于儿童接种。

Efficacy of Primary Immunization with Inactivated Hepatitis A Vaccine in 132 Young Children

Objective To evaluate the efficacy of primary immunization with the healive? Inactivated hepatitis A vaccine in local young children. Methods 132 susceptive healthy children, aged from two to six, who received inactivated hepatitis A vaccine for the first time were randomly divided into 4 groups. The local and the systemic adverse reactions were observed after vaccination and the seroconversion rate and geometric mean titers(GMT) of hepatitis A virus antibodies were evaluated at 1, 3, 6, and 7 months after the primary immunization. Results There was no local and systemic adverse reactions after immunized with the healive? Inactivated hepatitis A vaccine. The seroconversion rates of HAV antibody at 1, 3, 6, and 7 months after immunization were 100%, 97.83%, 100%, and 100%, respectively, while the GMT were 744.35mlU/ml, 524.41mlU/ml, 354.34mlU/ml, and 333.13mlU/ml, respectively. Conclusion The differences among the groups have no remarkable statistical significance. It indicates that the healive? Inactivated hepatitis A vaccine has excellent safety and immunogenicity in young children .The 250units/dose is appropriate for children.