辛伐他汀在治疗不稳定心绞痛中有益作用的观察与分析

目的：探明辛伐他汀在不稳定心绞痛治疗中的有益作用，方法：前瞻性，随机化设计，46例合并有轻，中度高脂血症的冠心病患，随机分为辛伐他汀组（26例）与对照组（20例），辛伐他汀用量为20－40mg/d，并至少已连续服用2个月以上，对照组不服用调脂药物，两组在心绞痛常规治疗上无区别，结果：Ridit统计分析显示，两组在心绞痛症状及心电图变化疗效上均存在显意义的差异（P＜0．05，P＜0．05）。辛伐他汀组明显优于对照组。结论：辛伐他汀在不稳定心绞痛治疗中，起着肯定的有益作用，并且早期应用可能即获益。

The Observation and Analysis of the Beneficial Effect in the Treatment of Unstable Angina

Objective: To verify the beneficial effect of simvastatin in the treatment of the unstable angina. Methods: According to prospective, randomized design, 46 cases with unstable angina complicated mild or moderate hyperlipemia were divided into simvas-tatin group (26 cases) and control group (20 cases). The patients in drug group had received simvastatin 20-40 mg/d, and at least over two months sequentially, while the control had received not any lipid - lowering agent. There were no differences between two groups in routine therapeutic scheme. Results: Ridit Statistic Analysis shows that there were significant differences in the therapeutic effect, both on the angina symptoms and electrocardiograph ST - T wave changes (P < 0.05, P<0.05). Simvastatin group was obviously better than the control. Conclusion: Simvastatin reveals the definite beneficial effect in treating the unstable angina and may get it in the early use.