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特比萘芬联合10%浓碘酊治疗甲真菌病疗效观察
引用本文:董文文,王亚洲.特比萘芬联合10%浓碘酊治疗甲真菌病疗效观察[J].临床合理用药杂志,2011(5):27-28.
作者姓名:董文文  王亚洲
作者单位:广西医科大学第四附属医院,广西壮族自治区柳州市545005
摘    要:目的观察特比萘芬联合10%浓碘酊外用治疗甲真菌病的疗效及安全性。方法将112例甲真菌病患者随机分为2组,治疗组60例给予特比萘芬片250mg口服,每天1次,连服7d后,改为隔日服用1次,指甲真菌感染患者连用7周,趾甲真菌感染患者连用9周;同时加用10%浓碘酊外涂,每天2次,指(趾)甲真菌感染患者连用时间分别为8周和10周。对照组52例给予特比萘芬片250mg口服,每天1次,指甲真菌感染患者连服8周,趾甲真菌感染患者连服10周。结果治疗组停药时、停药后6个月总有效率比较差异无统计学意义(P>0.05)。治疗组不良反应发生率为3.3%低于对照组的17.3%,差异均有统计学意义(P<0.05)。在疗效相当的情况下,治疗组所需药品费用低于对照组(P<0.05)。结论特比萘芬联合10%浓碘酊外用治疗甲真菌病临床疗效好,不良反应少,安全有效,节省治疗费用,值得临床推广应用。

关 键 词:特比萘芬  10%浓碘酊  甲真菌病

The effect observation of terbinafine combined 10% liquor iodi fortis in onychomycosis
DONG Wen-wen,WANG Ya-zhou.The effect observation of terbinafine combined 10% liquor iodi fortis in onychomycosis[J].Chinese Journal of Clinical Rational Drug Use,2011(5):27-28.
Authors:DONG Wen-wen  WANG Ya-zhou
Institution:.The No.4 Affiliated Hospital of Guangxi Medical University,Liuzhou,Guangxi 545005,China
Abstract:Objective To observe the effect and safety of terbinafine combined 10% liquor iodi fortis in onychomycosis.Methods 112 cases patients with onychomycosis were randomly divided into 2 groups,treatment group(60 cases) were treated with terbinafine 250mg,once a day for 7d,finger onychomycosis patients were treated with terbinafine in every other day for 7 weeks and toe onychomycosis patients for 9 weeks;Simultaneously,externally treated with 10% liquor iodi fortis,twice a day,finger onychomycosis patients treated for 8 weeks and toe onychomycosis patients treated for 10 weeks.Control group(52 cases) were treated with terbinafine 250mg,once a day,finger onychomycosis patients treated for 8 weeks and toe onychomycosis patients treated for 10 weeks.Results At the end of treatment and 6 months after treatment,the cure rates of treatment group was no significant difference(P0.05).The incidence of adverse reactions of treatment group(3.3%) was lower than that of control group(17.3%),there had significant difference(P0.05).In the case of a considerable effect,the drug costs of treatment group was lower than that of control group(P0.05).Conclusion Terbinafine combined 10% liquor iodi fortis in onychomycosis is effective,low-aderse drug reaction,save the cost of treatment.
Keywords:Terbinafine  10% liquor iodi fortis  Onychomycosis
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