血友病A患者血制品治疗后HBV和HCV感染指标分析

目的对血友病A患者替代治疗后血液传播乙型、丙型肝炎病毒(HBV、HCV)的感染指标进行检测。方法对经本院确诊的35例血友病A患者采用酶联免疫吸附法(ELISA)检测抗-HCV、HBV六项指标。结果 35例血友病A患者的抗-HCV阳性率为88.6%,输血次数和输注血液制品为主的种类与患者抗-HCV阳性率有相关性(P<0.01)。HBV六项指标检查,其中5例患者抗-HBe阳性(占14.3%),明显低于抗-HCV阳性率。结论血友病A患者替代治疗输血次数越多,感染风险越大,而较少输注以冷沉淀为主的血液制品的患者,其感染风险相对较小,且目前HCV感染率明显高于HBV感染率。

Analysis of Hepatitis B and C Virus after Injecting Blood Products to Patients with Hemophilia A

Objective To investigate the infectious status of hepatitis B virus(HBV) and hepatitis C virus(HCV) after injecting blood products in the patients with hemophilia A.Method The enzyme-linked immunosorbent assay(ELISA) was used to explore anti-HCV and HBV in 35 hemophilia A patients.Result In 35 hemophilia A patients investigated,the positive rates of anti-HCV were 88.6%.Factors of statistical significance(P<0.01) associated with the antiHCV were as follows:the times of blood transfusion and the types of blood products.The positive rate of hepatitis B e-antibody(anti-HBe)was 14.3%.Conclusion Hemophilia A patients are at higher risk of HCV infection than HBV,the times of blood transfusion and the main type of cryofibrinogen are more,the rate of hepatitis virus infection is higher.