Human CD4(+) memory T-lymphocyte responses to SARS coronavirus infection |
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Authors: | Libraty Daniel H O'Neil Kimberly M Baker Lauren M Acosta Luz P Olveda Remigio M |
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Institution: | Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA. daniel.libraty@umassmed.edu |
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Abstract: | Little is known about CD4(+) T-cell immunity to the severe acute respiratory syndrome (SARS) coronavirus. In two SARS patients, we examined the memory CD4(+) T-cell responses to peptides derived from SARS coronavirus structural proteins. We generated CD4(+) T-cell lines to 3 peptides from the spike (S) protein and defined their HLA restriction. In one patient, the predominant memory CD4(+) T-cell response was directed against an epitope outside the S protein receptor-binding domain. In both patients, the frequency of CD4(+) memory T-cells to virus structural proteins and anti-SARS coronavirus IgG levels were low by 12 months after infection. This report expands our understanding of the specificity and duration of anti-SARS coronavirus CD4(+) T-cell immune responses. |
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Keywords: | SARS Coronavirus CD4+ T-cell Immunity |
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