| 中期因子与脑膜瘤血管生成关系的研究 |
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| 引用本文： | 孙中书,李新军,徐宏,周增俊,曾义,韩扬云. 中期因子与脑膜瘤血管生成关系的研究[J]. 实用医技杂志, 2008, 15(33): 4733-4735 |
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| 作者姓名： | 孙中书 李新军 徐宏 周增俊 曾义 韩扬云 |
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| 作者单位： | 德阳市人民医院,四川德阳,618000 |
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| 摘 要： | 目的:探讨中期因子(MK)蛋白与脑膜瘤中血管生成关系。方法:采用S-P免疫组织化学技术,检测52例脑膜瘤组织和10例正常脑膜组织中MK蛋白的表达和微血管密度(MVD),并对二者的关系进行统计学分析。结果:52例脑膜瘤组织中,MK蛋白阳性表达率为63.5%,正常脑膜组织中无MK蛋白表达,明显低于肿瘤组织,差异有显著性(P<0.05)。MK蛋白阳性表达程度与MVD呈正相关(r=0.756,P<0.05),与肿瘤的血供(r=0.6518,P<0.05)密切相关。结论:MK蛋白在脑膜瘤组织中有过度表达;MK蛋白的表达与脑膜瘤血管生成相关;MK蛋白有望成为临床上对脑膜瘤生物学行为进行判定的指标。抑制MK的表达,有望为高表达MK的脑膜瘤提供一个新的治疗途径。
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| 关 键 词： | 脑膜瘤 中期因子蛋白 人原始造血细胞 微血管密度 免疫组织化学 |
Expression of midkine in meningioma and its biological value |
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| SUN Zhong-shu,LI Xin-jun,XU Hong,ZHOU Zeng-jun,ZENG Yi,HAN Yang-yun. Expression of midkine in meningioma and its biological value[J]. Journal of Practical Medical Techniques, 2008, 15(33): 4733-4735 |
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| Authors: | SUN Zhong-shu LI Xin-jun XU Hong ZHOU Zeng-jun ZENG Yi HAN Yang-yun |
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| Affiliation: | SUN Zhong-shu; LI Xin-jun; XU Hong; ZHOU Zeng-jun; ZENG Yi; HAN Yang-yun(The People’s Hospital of Deyang; Deyang; Sichuan 618000; China); |
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| Abstract: | Objective To investigate the expression of midkine(MK) in meningioma in relation to angiogenesis. Methods The expression of midkine protein levels and microvessel density (MVD) were detected by immunohisto- chemical technique(S-P) in 52 meningioma tissues and 10 human normal cerebral maters. At the same time , the clinical, screenage, and pathological parameters were statistically analyzed. Results The positive expression rate of midkine in the 52 cases was 63.5%. Otherwise the expression of midkine in huma... |
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| Keywords: | Meningioma Midkine CD34 Microvessel density Immunohistochemical |
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