HLA Alleles are Genetic Markers for Susceptibility and Resistance towards Leprosy in a Mexican Mestizo Population |
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| Authors: | Maribel Aguilar‐Medina Monica Escamilla‐Tilch Luis Octavio Frías‐Castro Geovanni Romero‐Quintana Iris Estrada‐García Sergio Estrada‐Parra Julio Granados Eliakym Arambula Meraz Guzman Sánchez‐Schmitz Shabaana Abdul Khader Javier Rangel‐Moreno Rosalío Ramos‐Payán |
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| Institution: | 1. Faculty of Biological and Chemical Sciences, Autonomous University of Sinaloa, Culiacán, Sinaloa, Mexico;2. Division of Immunogenetics, National Institute of Medical Sciences and Nutrition, CDMX, Mexico;3. Dermatological Hospital of Sinaloa, Culiacán, Sinaloa, Mexico;4. Department of Immunology, National School of Biological Science, National Polytechnic Institute, CDMX, Mexico;5. Division of Infectious Diseases, Boston Children's Hospital and Harvard Medical School, Harvard University, Boston, MA, USA;6. Department of Molecular Microbiology, Washington University, St. Louis, MO, USA;7. Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, School of Medicine and Dentistry, Rochester, NY, USA |
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| Abstract: | Despite the use of multidrug therapy, leprosy remains endemic in some countries. The association of several human leucocyte antigen (HLA) alleles and gene polymorphisms with leprosy has been demonstrated in many populations, but the major immune contributors associated to the spectrum of leprosy have not been defined yet. In this study, genotyping of HLA‐A, ‐B, ‐DR, and ‐DQ alleles was performed in leprosy patients (n = 113) and control subjects (n = 117) from the region with the highest incidence for the disease in México. The odds of developing leprosy and lepromatous subtype were 2.12‐ and 2.74‐fold higher in carriers of HLA‐A*28, and 2.48‐ and 4.14‐fold higher for leprosy and dimorphic subtype in carriers of DQB1*06. Interestingly, DQB1*07 was overrepresented in healthy individuals, compared to patients with leprosy (OR = 0.08) and the lepromatous subtype (OR = 0.06). These results suggest that HLA‐A*28 is a marker for predisposition to leprosy and the lepromatous subtype and DQB1*06 to leprosy and the dimorphic subtype, while DQB1*07 might be a resistance marker in this Mestizo population. |
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| Keywords: | Leprosy susceptibility HLA Mexicans |
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