The Role of TLR4, TNF‐α and IL‐1β in Type 2 Diabetes Mellitus Development within a North Indian Population |
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| Authors: | Natalie E. Doody Monika M. Dowejko Elizabeth C. Akam Nick J. Cox Jasvinder S. Bhatti Puneetpal Singh Sarabjit S. Mastana |
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| Affiliation: | 1. School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK;2. Department of Biotechnology and Bioinformatics, Sri Guru Gobind Singh College, Chandigarh, India;3. Department of Human Genetics, Punjabi University, Patiala, Punjab, India |
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| Abstract: | This study investigated the role of IL‐1β‐511 (rs16944), TLR4‐896 (rs4986790) and TNF‐α‐308 (rs1800629) polymorphisms in type 2 diabetes mellitus (T2DM) among an endogamous Northern Indian population. Four hundred fourteen participants (204 T2DM patients and 210 nondiabetic controls) were genotyped for IL‐1β‐511, TLR4‐896 and TNF‐α‐308 loci. The C allele of IL‐1β‐511 was shown to increase T2DM susceptibility by 75% (OR: 1.75 [CI 1.32–2.33]). Having two parents affected by T2DM increased susceptibility by 5.7 times (OR: 5.693 [CI 1.431–22.648]). In this study, we have demonstrated a conclusive association with IL‐1β‐511 locus and IL‐1β‐511‐TLR4‐896 diplotype (CC‐AA) and T2DM, which warrants further comprehensive analyses in larger cohorts. |
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| Keywords: | Type 2 diabetes mellitus TLR4 896 TNF‐α ‐308 IL‐1β ‐511 Inflammatory gene polymorphisms North Indian population |
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