An immunosuppressive regimen using FTY720 combined with cyclosporin in canine kidney transplantation |
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Authors: | S Suzuki Toshihiro Kakefuda Hiroshi Amemiya Kenji Chiba Yukio Hoshino Takafumi Kawaguchi Hirotoshi Kataoka Fazlur Rahman |
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Institution: | (1) Department of Experimental Surgery, and Bioengineering, National Children's Medical Research Center, 3-35-31 Taishido, Setagaya-ku, Tokyo 154 Japan Fax: +81 3 34 11 73 09 e-mail: ssuzuki@nch.go.jp, JP;(2) Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd. Saitama, Japan, JP |
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Abstract: | FTY720 induces apoptosis, specifically in lymphocytes, and prolongs allograft survival in rats and dogs. The purpose of this
study was to define an effective range of FTY720 doses that could be combined with a suboptimal dose (10 mg/kg) of cyclosporin
for canine kidney allograft recipients. The combination significantly prolonged allograft survival in all groups receiving
FTY720 at a dose of 0.1, 0.3, 1.0, or 3.0 mg/kg. None of the recipients died due to notable side effects of the drug. In peripheral
blood, the number of lymphocytes was extremely low, whereas the percentage of granulocytes increased during FTY720 administration.
No significant difference in cyclosporin trough levels was observed between the cyclosporin-alone group and the combination
groups. We conclude from the present study that FTY720 has a potent effect at an extremely low dose and a wide therapeutic
window when combined with cyclosporin in canine kidney transplants.
Received: 16 May 1997 Received after revision: 6 October 1997 Accepted: 19 November 1997 |
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Keywords: | FTY720 kidney transplantation canine Kidney transplantation canine FTY720 Canine kidney transplantation FTY720 |
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