| 血管紧张素Ⅰ转化酶基因多态和2型糖尿病高血压相关性的研究 |
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| 引用本文： | 许玲,任建民,马玉燕,南海蓉,程梅,王德全.血管紧张素Ⅰ转化酶基因多态和2型糖尿病高血压相关性的研究[J].山东大学学报(医学版),1999(2). |
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| 作者姓名： | 许玲 任建民 马玉燕 南海蓉 程梅 王德全 |
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| 作者单位： | 山东医科大学附属医院，滨州地区人民医院 |
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| 摘 要： | 为研究血管紧张素Ⅰ转化酶（ＡＣＥ）基因第１６内含子插入／缺失（Ｉ／Ｄ）多态和糖尿病合并高血压的关系，应用ＰＣＲ技术检测４０例中国汉族２型糖尿病高血压患者和４０例无高血压患者ＡＣＥ基因Ｉ／Ｄ多态基因型。结果表明，高血压组和无高血压组相比，Ｄ型等位基因的频率增高（６２．５％ｖｓ４７．５％，χ２＝３．６４，Ｐ＞０．０５，ＯＲ＝１．８４，９５％ＣＩ１．３４～２．５２），但无统计学意义。高血压组ＤＤ基因型的频率也增高（３７．５％ｖｓ１７．５％，χ２＝４．０１，Ｐ＜０．０５，ＯＲ＝２．８３，９５％ＣＩ２．３６～６．７３）。提示携带ＤＤ基因型的２型糖尿病患者有高血压易感性。
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| 关 键 词： | 基因.ACE 糖尿病.非胰岛素依赖型 高血压 |
ASSOCIATION BETWEEN AN INSERTION/DELETIONPOLYMORPHISM OF ANGIOTENSIN I CONVERTING ENZYMEGENE AND TYPE 2 DIABETICS WITH HYPERTENSION |
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| Xu Ling,Ren Jianmin,Ma Yuyan,et al.ASSOCIATION BETWEEN AN INSERTION/DELETIONPOLYMORPHISM OF ANGIOTENSIN I CONVERTING ENZYMEGENE AND TYPE 2 DIABETICS WITH HYPERTENSION[J].Journal of Shandong University:Health Sciences,1999(2). |
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| Authors: | Xu Ling Ren Jianmin Ma Yuyan |
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| Abstract: | In order to study the association between an I/D polymorphism of ACE gene and diabetic hypertension, PCR technique was used to determine the ACE gene genotypes in Chinese type 2 diabetics with hypertenison (n=40) and without hypertension (n=40). The results showed that D type allele was prevalent in hypertensive group (62.5% vs 47.5%,2=3.64, P>0.05,OR=1.84,95% CI 1.342.52),but is not statistically different. Distribution of DD genotype is significantly diffetent between the 2 groups (37.5% vs 17.5%,2=4.01, P<0.05,OR=2.83,95% CI 2.366.73).It is suggested that type 2 Chinese diabetics carrying DD genotype are susceptible to hypertension. |
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| Keywords: | Gene ACE Diabetes Mellitus noninsulindependent Hypertension |
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