Prospective clinical evaluation of the serologic tuberculous glycolipid test in combination with the nucleic acid amplification test |
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Authors: | Maekura Ryoji Kohno Hiroaki Hirotani Atsushi Okuda Yoshinari Ito Masami Ogura Takeshi Yano Ikuya |
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Institution: | Toneyama National Hospital, Osaka, Japan. maekurat@toneyama@toneyama.hosp.go.jp |
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Abstract: | We have conducted a prospective controlled multicenter study to evaluate differences in the levels of clinical utility of the tuberculous glycolipid (TBGL) serodiagnostic test and the nucleic acid amplification test in patients with smear-negative active pulmonary tuberculosis (TB). The TBGL test and the PCR test were individually not so useful for the rapid diagnosis of smear-negative active pulmonary TB. However, clinical utility was considerably improved by using the TBGL test and the PCR test in combination, especially in patients with smear-negative and culture-negative active pulmonary TB and in patients with minimally advanced lesions. |
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