阿昔洛韦联合高能红光和窄谱中波紫外线治疗免疫功能下降带状疱疹患者的疗效观察

目的比较阿昔洛韦联合高能红光和窄谱中波紫外线与单用阿昔洛韦治疗免疫功能下降带状疱疹患者的疗效,寻求一种更好的治疗方法。方法 64例免疫功能下降带状疱疹患者随机分为试验组和对照组。试验组采用阿昔洛韦静脉滴注联合高能红光照射支配皮损区域的神经根体表投射部位和窄谱中波紫外线照射皮损局部,对照组单独静脉滴注阿昔洛韦,疗程均为14d,随访1个月。结果试验组有效率为90.63%,高于对照组（68.75%）（P=0.011）;试验组开始结痂时间、结痂脱落时间、疼痛开始缓解时间、疼痛基本缓解时间均低于对照组（P〈0.001）。两组患者止疱时间、后遗神经痛发生率比较,差异无统计学意义（P〉0.05）。结论阿昔洛韦联合高能红光和窄谱中波紫外线治疗免疫功能下降并发带状疱疹患者的疗效优于单用阿昔洛韦者。

Effect of acyclovir combined with narrow-band ultraviolet-B radiation and Carnation 33 NM-B in treating immunocompromised host with herpes zoster

Objective To compare the effect of acyclovir combined with narrow-band ultraviolet-B radiation （NB-UVB） and Carnation 33 NM-B with that of acyclovir in the treatment of herpes zoster in immunocompromised patients. Methods Sixty-four immunocompromised patients with herpes zoster were divided into two groups, test group and control group randomly. The test group was treated with acyclovir combined with NB-UVB and the Carnation 33 NM-B; while the control group was treated with acyclovir. The efficacy was observed 14 days after treatment and the follow-up had been carried out for more than 1 months. Results The effective rate was 90.63% in the test group versus 68.75% in the control group （P=0.011）. The effect of test group on vesicular scab, subside, pain relief and pain complete remission time was superior to that of the control group （P〈0.001）. There were no significant differences between the blister stopped time and possibly neuralgia incidence in the test group and those in the control group （P 0.05）. Conclusion The treatment with acyclovir combined with NB-UVB and the Carnation 33 NM-B is superior to acyclovir in immunocompromised patients with herpes zoster.