头颈部原发性结外淋巴瘤146例临床分析

目的探讨原发于头颈部的结外型淋巴瘤的临床特点和误诊原因，为该病的诊治提供经验。方法选取2001-2011年诊治的146例原发于头颈部并经病理证实为结外型淋巴瘤患者，对其临床资料进行回顾性分析。结果146例患者根据病检结果及病情采取不同的治疗方案；其中3年生存率为55％，5年生存率为41％。不同部位及不同病理类型生存率有明显差异。结论原发于头颈部的结外型淋巴瘤可发于多个部位，部分位置隐蔽，不易发觉，临床症状无特异性，及时针刺活检和术中快速病理切片可提高诊断率和患者生存率。

Primary extra nodal lymphoma of head and neck: A clinical analysis of 146 casesTIAN Hao, WANG Wei, ZENG Liang, et al.

Objective To discuss the clinical features of primary extra nodal lymphoma in head and neck region and to summarize the causes of misdiagnosis. Methods Clinical data of 146 patients with pathologically confirmed primary extra nodal lymphoma in head and neck was analyzed retrospectively. Results Of all the 146 patients, 86 were male and 60 were female. As for the primary lesions, the lymphoma located in nasopharynx in 50 cases, tonsil in 42, thyroid gland in 33, nasal cavity in 11 , larynx in 3, major salivary glands in 2 cases, root of tongue in 2, hard palate in one, scalp in one, and buccal mucosa in one. Conclusions Primary extra nodal lymphoma may occur at multiple sites of head and neck. This disease is usually misdiagnosed due to its hidden primary lesion, nonspecific clinical symptoms, and clinicians＇ lack of awareness. To improve the diagnosis rate and to avoid inappropriate treatment, the suspected patients should be followed up strictly, timely （aspiration） biopsy and intra-operative rapid pathologic examination should be performed if necessary.