| ELSD-HPLC法监控维生素C生产过程 |
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| 引用本文： | 耿文飞,王惠欣,蔡超靖,吴洪涛,贾茜.ELSD-HPLC法监控维生素C生产过程[J].中国医药工业杂志,2005,36(9):539-540. |
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| 作者姓名： | 耿文飞 王惠欣 蔡超靖 吴洪涛 贾茜 |
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| 作者单位： | 华北制药集团新药研究开发有限责任公司,河北,石家庄,050015 |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | 建立了ELSD-HPLC法监控由山梨醇生产维生素C的过程.采用氨基色谱柱,流动相为0.1%三氟乙酸-乙腈(梯度洗脱).4种成分均在0.025%～0.4%范围内线性关系良好.平均回收率分别为98.7%、100.5%、100.8%和100.4%.
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| 关 键 词： | 维生素C 高效液相色谱 蒸发光散射检测器 |
| 文章编号： | 1001-8255（2005）09-0539-02 |
| 收稿时间： | 2004-07-23 |
| 修稿时间： | 2004-07-23 |
Vitamin C Production Process Monitored by ELSD-HPLC |
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| Authors: | GENG Wen-Fei WANG Hui-xin CAI Chao-Jing WU Hong-tao JIA Qian |
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| Abstract: | An ELSD-HPLC method to monitor the whole course of vitamin C production process from D-sorbitol was established. A NH2 column was used with the mobile phase of 0.1% trifluoroacetic acid-acetonitrile by gradient elution.The calibration curves of all the four compounds were linear in the range of 0.025% - 0.4%. The average recoveries were 98.7%, 100.5%, 100.8% and 100.4%, respectively. |
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| Keywords: | vitamin C HPLC ELSD |
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