病原体的组织特异性对靶向制剂研发的启示

靶向给药是指通过靶向载体将药物选择性地输送到靶部位,可减少药物全身分布从而减少用药的剂量和给药次数,提高药物的治疗指数和降低药物不良反应,为相关疾病的诊断和治疗开辟了广阔的前景。近年来,高效特异的靶向载体/导向分子研究已成为科研人员研究和探索的热点之一。很多病原体对宿主组织具有高度选择性,研究显示这种特异选择性涉及受体-配体间的相互作用,了解病原体组织特异性的分子机制,从中得到启发,为设计、研发高效、安全、特异的靶向制剂提供了新思路。

Revealing research into targeted preparations that target pathogens in a tissue-specific manner

Using targeted vectors to target specific cells or tissues with drugs is an attractive strategy in terms of improving the efficacy and safety of therapeutic agents.This approach results in accumulation of a drug in target tissues and it also decreases potential adverse effects on untargeted tissues.Targeting may be a strategy that facilitates the diagnosis and treatment of related diseases.However,the choice of a targeted vector must be optimized to improve response and reduce the adverse effects of vectors.Various researchers have used different approaches to investigate targeted vectors.Numerous microorganisms have developed highly effective organ-specific targeting strategies for host invasion.The rapid and tissue-specific targeting of microorganisms is the result of interaction between receptors and ligands.Understanding the molecular mechanisms for tissue-specific targeting of pathogens may provide new insight into the design and development of targeted preparations that are efficient,safe,and specific