| 结核分枝杆菌双组分系统MprAB的研究进展 |
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| 引用本文： | 王钊,张万江. 结核分枝杆菌双组分系统MprAB的研究进展[J]. 中国病原生物学杂志, 2014, 0(6): I0001-I0004 |
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| 作者姓名： | 王钊 张万江 |
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| 作者单位： | 石河子大学医学院病理生理学教研室,石河子大学“新疆地方与民族高发病”教育部重点实验室,新疆石河子832002 |
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| 基金项目： | 国家自然科学基金项目（No.81260261,8u60192）;新疆生产建设兵团医药专项资金项目（No.2012BA022）. |
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| 摘 要： | 双组分系统(two component system,TCS)是结核分枝杆菌(Mycobacterium Tuberculosis,MTB)感应环境因素刺激,并作出相应反应,以适应环境变化的一种跨膜信号转导系统。MprAB作为MTB目前发现的11个完整的TCS之一,与MTB的持留性及调节应激反应等方面密切相关,本文就MTB MprAB TCS的研究进展进行了综述。
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| 关 键 词： | 结核分枝杆菌 双组分系统MprAB 综述 |
Advances in the study of the MprAB two-component system and Mycobacterium tuberculosis |
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| WANG Zhao,ZHANG Wan-jiang. Advances in the study of the MprAB two-component system and Mycobacterium tuberculosis[J]. Journal of Pathogen Biology, 2014, 0(6): I0001-I0004 |
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| Authors: | WANG Zhao ZHANG Wan-jiang |
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| Affiliation: | (Department of Pathophysiology, Medical School of Shihezi University, Xinjiang Key Laboratory of Endemic and Ethnic Diseases, Shihezi University, Shihezi, Xingjiang 832002, China) |
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| Abstract: | Two-component systems （TCSes） in Mycobacteriurn tuberculosis are transmembrane signal transduction systems that can induce a commensurate response to stimulation by environmental factors and adaptation to changes in the environment. MprAB is one of the eleven TCSes in M. tuberculosis, and MprAB is closely related to the persistence of M. tuberculosis and regulation of its response to stress. This review summarizes advances in the study of the MprAB TCS of M. tuberculosis. |
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| Keywords: | Mycobacteriurn tuberculosis MprAB two-component system review |
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