| 急性缺氧时左室舒张功能障碍与心肌细胞肌浆网钙摄取功能的变化 |
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| 引用本文： | 孙尧,李万镇,陈永红,齐鹰,祁大勇,胡存栋. 急性缺氧时左室舒张功能障碍与心肌细胞肌浆网钙摄取功能的变化[J]. 中国综合临床, 1997, 0(1) |
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| 作者姓名： | 孙尧 李万镇 陈永红 齐鹰 祁大勇 胡存栋 |
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| 作者单位： | 北京医科大学第一医院!100034(孙尧，李万镇，陈永红，齐鹰)，开滦矿务局马家沟矿医院(祁大勇)，开滦矿务局吕家坨矿医院(胡存栋) |
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| 摘 要： | 临床上心室舒张功能障碍越来越引起人们的重视。为了研究急性缺氧在室舒张功能障碍时心肌细胞内肌浆网钙摄取功能，探讨左室舒张功能障碍发生的机理，该文用实验方法模拟临床上急性缺氧时左心室舒张功能障碍的情况（实验组）。测定实验组和对照组心肌细胞肌浆网摄钙量和肌浆网钙ATP酶活性。结果显示，实验组肌浆网摄钙量为57.65.4nmolCa2 ／mgPr，对照组96．17．2nmolCa2 ／mgPr，二者差别有显著性；实验组钙ATP酶活性为11．40．6μmol/pi/（mgPr．h）。对照组为22．71．4μmolPi/（mgPr·h）。结果表明．急性缺氧左心室舒张功能障碍时，心肌细胞肌浆网钙摄取功能下降。
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| 关 键 词： | 缺氧 心室舒张 肌浆网 |
CARDIAC SARCOPLASMIC RETICULUM Ca~(2 )-UPTAKE AND Ca~(2 )-ATPase ACTIVITY IN ACUTE ANOXIAINDUCED LEFT VENTRICULAR DIASTOLIC DYSFUNCTION |
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| Sun Yao, Qi Dayong, Hu Cundong,et a.. CARDIAC SARCOPLASMIC RETICULUM Ca~(2 )-UPTAKE AND Ca~(2 )-ATPase ACTIVITY IN ACUTE ANOXIAINDUCED LEFT VENTRICULAR DIASTOLIC DYSFUNCTION[J]. Clinical Medicine of China, 1997, 0(1) |
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| Authors: | Sun Yao Qi Dayong Hu Cundong et a. |
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| Abstract: | The animal models of acute anoxia-induced left ventricular diastolic bysfunction were made inorder to research the mechanism of diastolic dysfunction and the cardiac sarcoplasmic reticulum Ca2 -uptake andCa2 -ATPase activity. The resu1t showed that sarcoplasmic reticulum Ca2 -uptake and Ca2 -ATPase activity.decreased significantly in group of experimental animals. We suggested that a decrease in sarcoplasmic reticulumCa2 -uptake and Ca2 -ATPase activity was one of the causes of acrte anoxia-induced left ventricular diastolicdysfunction. |
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| Keywords: | Anoxia Ventricular diastole Sarcoplasmic reticulum |
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