| 骨折后早期血管发生与骨形成的免疫组化及超微结构分析 |
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| 引用本文： | 李文革,刘国平,李继云,杨昀焯,康斌,李国新,熊(百乔). 骨折后早期血管发生与骨形成的免疫组化及超微结构分析[J]. 中国基层医药, 2002, 9(11): 972-973 |
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| 作者姓名： | 李文革 刘国平 李继云 杨昀焯 康斌 李国新 熊(百乔) |
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| 作者单位： | 518036,深圳,北京大学深圳医院骨科 |
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| 摘 要： | 目的：探讨早期血管重建与骨折愈合的关系，为临床治疗骨折愈合及骨不连提供理论依据。方法：选择成龄Wistar大鼠，于右侧胫骨中段闭合性骨折，按观察时间分为四组（12h、24h、48h、72h）。采用血管标记物一层粘蛋白，用免疫组化结合超微结构观察骨折区血管重建。结果：骨折区随时间延长有大量血管增殖，以48h明显，成骨也随血管增殖逐渐显著。结论：骨折早期血管增殖对成骨活动具有重大影响。提示早期应用血管刺激因子可能加快骨折愈合。
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| 关 键 词： | 骨形成 骨愈合 血管生成 免疫组织化学 超微结构 骨不连 |
| 修稿时间： | 2002-09-19 |
The study of angiogenesis and osteogenesis in the early stage of fracture by immunohistochemistry and hultrastructure |
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| LI Wenge.LIU Guoping,LI Jiyun,et al.. The study of angiogenesis and osteogenesis in the early stage of fracture by immunohistochemistry and hultrastructure[J]. Chinese Journal of Primary Medicine and Pharmacy, 2002, 9(11): 972-973 |
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| Authors: | LI Wenge.LIU Guoping LI Jiyun et al. |
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| Affiliation: | LI Wenge.LIU Guoping,LI Jiyun,et al.Department of Orthopedics,Shenzhen Hospital,Beijing University,Guangdong,518036. |
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| Abstract: | Objective The purpose of this study was to investigate the relationship between angiogenesis and bone healing in the early stage.Methods Immunohistochemistry and transmission microscope,laminin was used as a vascular marker,the fracture time:12h,24h,48h,72h.Results There were many veseks in the fracture region,the vessels proliferated evidently at 48h,with the vessels proliferating,osteogenesis was more prominent.Conclusion The angiogenesis at early stage could make more influences on osteogenesis.The vascular EC might be a major member on the course of fracture healing. |
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| Keywords: | Bony union Angiogenesis Ostesgensis Immnuohistochemistry hultrastructure |
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