恶性胃肠道间质瘤的临床病理特点及治疗

目的 评价恶性胃肠道间质瘤(GIST)患者的临床表现、组织学和免疫组化的特点及治疗方法。方法 对30例恶性GIST患者的临床和组织学资料进行回顾性分析，并研究免疫组化染色CD34、CD117、血清蛋白和血清单克隆抗体的表达情况。结果 恶性GIST原发肿瘤部位主要为胃贲门、小肠和大肠：主要症状和体征有腹痛、腹部肿块、贫血和黑便。结论 CD117和CD34标记阳性是确诊GIST最有价植的诊断依据，恶性GIST的最后诊断需靠病理切片；该病预后较差，手术是主要治疗手段，但提高疗效需要综合治疗。对于复发或转移者缺乏有效的治疗方法，需要寻找新的有效药物和治疗方法来提高治疗水平。

Clinicopathologic characteristics and treatment of malignant gastrointestinal stromal tumor

Objective To evaluate the clinical feature and histopathological characteristics of gastrointestinal stromal tumor (GST) and its treatment.Methods Clinical data of 30 cases of GST were retrospectively analyzed,and the expressions of CD34,CD117,S-100 and SMA were studied.Results The primary tumors were located in cardia,small intestinal and large intestinal,with major symptoms and signs like abdominal pain,abdominal mass,anemia and hemafecia.Conclusion Positively marked CD117 and CD34 is the most valuable diagnosis evidence,but the final diagnosis of malignant GST depends on the pathological slice.Since the prognosis is very poor,the treatment resorts to operation,but comprehensive treatment are necessary to improve clinical efficacy.New effective drug and treatment are needed to improve treatment level on the condition of the lack of effective treatment method for recurrent or metastasis disease.