Tie2-expressing monocytes and tumor angiogenesis: regulation by hypoxia and angiopoietin-2 |
| |
Authors: | Lewis Claire E De Palma Michele Naldini Luigi |
| |
Institution: | Tumor Targeting Group, Academic Unit of Pathology, The Sir Henry Wellcome Laboratories for Medical Research, University of Sheffield Medical School, Sheffield, United Kingdom. claire.lewis@sheffield.ac.uk |
| |
Abstract: | Recent findings indicate that tumor-associated macrophages are important drivers of tumor angiogenesis. Here, we review the essential role played by Tie2-expressing monocytes (TEM) in this phenomenon. TEMs are present in human blood and tumors and their elimination in various tumor models suppresses tumor angiogenesis. A ligand for Tie2, angiopoietin-2 (Ang-2), is produced by angiogenic tumor vessels and is a chemoattractant for TEMs. Hypoxia up-regulates Tie2 expression on TEMs and, together with Ang-2, down-regulates their antitumor functions. Learning more about the regulation of TEMs by the tumor microenvironment may yield new strategies to ablate the tumor vasculature. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|