EFFECT OF CAPTOPRIL ON BLOOD PRESSURE AND BRADYKININ VASODEPRESSOR RESPONSES AFTER NEPHRECTOMY AND SUPPRESSION OF PROSTAGLANDIN SYNTHESIS IN ANAESTHETIZED RATS |
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| Authors: | R. Vandongen A. Barden A. Tunney D. Mahoney |
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| Affiliation: | Department of Medicine, University of Western Australia, Royal Perth Hospital, Perth, Western Australia |
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| Abstract: | 1. Captopril markedly potentiated the vasodepressor responses to bradykinin. Neither the magnitude nor duration of the blood pressure fall were altered by bilateral nephrectomy or treatment with indomethacin which suppressed urinary excretion of the prostacyclin metabolite 6-Keto PGF1a. 2. It is concluded that in the anaesthetized rat augmentation of the bradykinin depressor responses by captopril occurs independently of endogenous prostaglandin synthesis. |
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| Keywords: | bradykinin captopril prostacyclin renin |
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