Markers of haemostasis and angiogenesis in placentae from gestational vascular complications: Impairment of mechanisms involved in maintaining intervillous blood flow |
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Authors: | Elena Chinni Giovanni L Tiscia Giuseppe M Maruotti Maurizio Margaglione Elvira Grandone |
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Institution: | a Atherosclerosis and Thrombosis Unit, I.R.C.C.S. Casa Sollievo della Sofferenza, S.Giovanni Rotondo, FOGGIA, ITALY b Medical Genetics, University of Foggia, FOGGIA, ITALY c Obstetrics and Gynaecology, University Federico II, NAPLES, ITALY d Obstetrics and Gynaecology, University of Foggia, FOGGIA, ITALY |
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Abstract: | IntroductionPreeclampsia (PE) and fetal growth restriction (FGR) are multifactorial diseases, whose pathogenesis is largely unknown. A significant relationship between haemostasis and angiogenesis in placentae from uneventful pregnancies was previously shown.Materials and MethodsRNA expression of haemostasis (TF, TFPI, TFPI-2, PAI-2, Anx V, TM) and angiogenesis (Ang-1, Ang-2, PlGF, VEGF) markers in placentae from PE (n = 12), PE+FGR (n = 17) and FGR (n = 20) in respect of placentae from uncomplicated pregnancies (n = 21) were investigated.ResultsPlacentae from complicated pregnancies showed a significant lower expression (p ≤ 0.05 Mann-Whitney U test) of TF, TFPI, TFPI-2, Anx V, PAI-2 than those from in uncomplicated ones. VEGF and PlGF were not different in the considered groups; Ang-1 and Ang-2 were significantly higher (p ≤ 0.05 Mann-Whitney U test) in the PE group.Correlations between factors involved in haemostasis and those involved in angiogenesis, observed in placentae from uneventful pregnancies are lacking in those from complicated ones.ConclusionsHaemostasis factors are reduced in placentae from complicated pregnancies. The relationship between haemostasis and angiogenesis observed in uncomplicated pregnancies is impaired in PE and FGR. |
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Keywords: | PE preeclampsia FGR fetal growth restriction TF tissue factor TFPI Tissue Factor Pathway Inhibitor PAI Plasminogen Activator Inhibitor AnxV Annexin V TM Thrombomodulin Ang-1 and 2 Angiopoietin 1 and 2 VEGF Vascular Endothelial growth Factor PlGF Placental Growth Factor |
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