Non-Viral Causes of Hepatocellular Carcinoma

Introduction

Hepatocellular carcinoma (HCC) is a major cause of cancer worldwide. The vast majority of cases occur in individuals with a chronic HBV or HCV infection. In addition, a number of metabolic diseases of the liver are associated with the development of HCC.

Pathophysiologic Mechanisms

The mechanisms responsible for the progression of the metabolic liver disease and HCC differ from those associated with viral liver disease.

Conclusions

The purpose of this report is to describe the mechanisms responsible for the disease progression and HCC in case of metabolic liver disease. A secondary goal is to identify the frequency of HCC development in the disorders described.