| 氯胺酮对大鼠不同脑区NOS活性和NO产量的影响 |
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| 引用本文： | 胡兴国,王钧,曾因明,段世明,许鹏程.氯胺酮对大鼠不同脑区NOS活性和NO产量的影响[J].临床麻醉学杂志,1999,15(1):27-29. |
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| 作者姓名： | 胡兴国 王钧 曾因明 段世明 许鹏程 |
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| 作者单位： | 1. 湖南省桃源县人民医院麻醉科,415700
2. 徐州医学院麻醉医学研究所附属医院麻醉科 |
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| 摘 要： | 目的：了争氯胺酮对大鼠脑ＮＯＳ活性和ＮＯ产量的影响。方法：１６只ＳＤ大鼠，随机分为二组，分别ｉｐ生理盐水１０ｍｌ／ｋｇ（对照组）和氯胺酮１００ｍｇ／ｋｇ。用分光光度法测定ＮＯＳ活性和ＮＯ产量。结果：大鼠ｉｐ氯胺酮１００ｍｇ／ｋｇ能明显抑制小脑、大脑皮层、海马的ＮＯＳ活性和减少ＮＯ的产量（Ｐ〈０．０５或Ｐ〈０．０１），脑干的ＮＯ产量亦较对照组减少（Ｐ〈０．０１），ＮＯＳ活性下降，但无统计学意义。结论
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| 关 键 词： | 氯胺酮 一氧化氮合酶 一氧化氮 |
Effects of Ketamine on Nitric Oxide Synthase Activity and Nitric Oxide Production of Rat Brain in Vivo |
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| Hu Xingguo,WangJun,Zeng Yinming,et al Research Institute of Anesthesiology,Xu Zhou Medical College.Effects of Ketamine on Nitric Oxide Synthase Activity and Nitric Oxide Production of Rat Brain in Vivo[J].The Journal of Clinical Anesthesiology,1999,15(1):27-29. |
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| Authors: | Hu Xingguo WangJun Zeng Yinming Research Institute of Anesthesiology Xu Zhou Medical College |
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| Abstract: | Objective: To investigate effects of ketamine on nitric oxide synthase (NOS) activity and nitric oxide (NO) production of rat brain. Methods: Sixteen SD rats were divided randomly into two groups. The aminals were administred introperitoneally (ip) normal saline 10ml/kg (control group) or ketamine 100mg/kg (ketamine group) respectively. NOS activity and NO production were assassed by spectrophotometric analysis. Results: Ketamine 100mg/kg ip significantly inhibited NOS activity of the cerebellum, cerebral cortex and hippocampus and significantly reduced NO production of the cerebellum, cerebral cortex, hippocampus and brainstem as compared with that of control group ( P< 0 05 or P< 0 01). Conclusion: Ketamine has a significant effect on NOS activity and NO production of rat brain. It is suggested that NO may play an important role in the molecular mechanism of ketamine anesthesia. |
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| Keywords: | Ketamine Nitric oxide synthase (NOS) Nitric Oxide (NO) |
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