Lucanthone hydrochloride in the treatment of Schistosoma mansoni infection |
| |
| Authors: | R E Lees |
| |
| Affiliation: | 1. Vector-Borne Bioagents Laboratory (VBBL), Department of Pathology, Reproduction and One Health, School of Agricultural and Veterinarian Sciences, São Paulo State University (Unesp), Via de Acesso Prof. Paulo Donato Castellane, s/n, Zona Rural, Jaboticabal, 14884-900, São Paulo, Brazil;2. Department of Veterinary Medicine, University of Bari, 70100, Valenzano, Italy;3. Faculty of Veterinary Sciences, Bu-Ali Sina University, 6516738695, Hamedan, Iran;4. Post-Graduation of Ecology and Conservation, Mato Grosso do Sul Federal University, Campo Grande, 13471-410, Mato Grosso do Sul, Brazil;5. Laboratory of Parasitic Biology, Environmental Sciences and Farming Sustainability, Dom Bosco Catholic University, Campo Grande, 13471-410, MS, Brazil |
| |
| Abstract: | 29 patients suffering from S. mansoni infection were treated from an out-patient clinic. They were aged 5–65 years and each patient was given lucanthone hydrochloride in a total dosage of 60 mg. per kg. body weight; the total dosage was administered in 6 unequal doses over a period of 3 days. The cure rate after 6 months was 82·7%, 4 of the 5 uncured either relapsing or being re-infected between the 12th and 26th week.Side effects were common (in 26 of the 29 patients) despite the routine administration of cyclizine hydrochloride before each dose of lucanthone. Dizziness, nausea and vomiting were the most frequent, but were in no case so intolerable that treatment had to be suspended. Children suffered less from side-effects than adults.It is concluded that lucanthone hydrochloride is valuable against S. mansoni infection and can be used on a large scale within a control or eradication programme. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
