不同海拔地区健康儿童气体信号因子一氧化氮及硫化氢的变化

目的探讨气体信号因子一氧化氮(NO)及硫化氢(H2S)在不同海拔地区健康儿童中的含量差异。方法2005-06—2006-02，将随机选取的北京市和青海省海北州体检时的健康儿童青少年，按照不同海拔分组：北京地区(平均海拔43.5m)17名，男11名，女6名，年龄(7.28±4.79)岁；青海省海北州地区(平均海拔3200m以上)25名，男12名，女13名，年龄(10.42±0.49)岁。均空腹取肘静脉血，采用Griess法测定血清NO浓度，敏感硫电极法测定血清H2S的浓度。结果北京地区健康儿童血清中NO浓度(60.58±16.85)μmol/L，低于青海省海北州地区健康儿童血清中NO浓度(73.88±18.97)μmol/L；北京地区健康儿童血清中H2S浓度(65.55±9.07)μmol/L，高于青海省海北州地区健康儿童血清中H2S浓度(46.92±6.46)μmol/L。结论高海拔地区健康儿童血清中NO浓度明显高于低海拔地区，而H2S浓度则明显低于低海拔地区。

Changes of gasotransmitters nitric oxide and hydrogen sulfide in healthy children in areas of different altitudes.

AbstractObjectiveTo explore the difference in the contents of gasotransmitters nitric oxide (NO) and hydrogen sulfide (H2S) in healthy children in areas of different altitudes.MethodsForty-two healthy children were divided by different altitudes.Seventeen children (11 boys and 6 girls,at the age of 7.28±4.79) were from the area of Beijing (the average altitude is 43.5 metres) and 25 (12 boys and 13 girls,at the age of 10.42±0.49) from Haibei state in Qinghai province (the average altitude is above 3200 metres).The serum was sampled on a fasting state.The contents of NO and H2S in the serum were measured by Griess and sensitive sulfur electrode.ResultsThe content of NO in the serum of healthy children in the area of Beijing was 60.58±16.85 μmol/L,which was much lower then that of Haibei state in Qinghai province (73.88±18.97 μmol/L); the content of H2S in the serum of healthy children in the area of Beijing was 65.55±9.07 μmol/L,which was much higher than that of Haibei state in Qinghai province (46.92±6.46 μmol/L).ConclusionThe content of NO in the serum of healthy children in the area of high altitude is much higher than that in the area of low altitude,while the content of H2S in the serum of healthy children in the area of high altitude is much lower than that in the area of low altitude.