尼莫地平、脑活素对缺氧缺血性脑病新生儿预后的影响

目的：探讨尼莫地平、脑活素对缺氧缺血性脑病（Hypoxic—Ischemic Encephalopathy，HIE）新生儿预后的改善及保护作用。方法：将146例HIE患儿随机分为观察组（76例）和对照组（70例）。对照组行常规治疗，观察组在常规治疗的基础上于生后48h内加用尼莫地平、脑活素治疗。所有患儿日龄12—14d和26—28d行新生儿行为神经评分（NBNA）；3、6个月龄时行智测检查。结果：中、重度HIE，观察组两次NBNA评分和智能发育评估均优于对照组（P〈0．05，P〈0．01）。结论：早期应用尼莫地平、脑活素能明显改善中、重度HIE患儿预后。

Effects of Nimodipine and Cerebrolysin on Prognosis of Newborn with Hypoxic-Ischemic Encephalopathy

Objective:To study the effects of nimodipine and cerebrolysin on prognosis of Newborn with Hypoxic-Ischemic Encephalopathy. Method:One hundren and forty-six newborns with HIE were randomly divided into 2 groups.In control group(n=70),the treatment was common.In experimental group(n=76), Nimodipine and cerebrolysin were used within 48 hours after birth except for routine therapy. NBNA was performed at 1214 days and 2628 days old in all patients;Intelligence test was also performed at 3rd and 6th month after birth. Result:The moderate and severe HIE,NBNA score and mental development were better in experimental group than those in control group in every time(P<0.05,P<0.01). Conclusion:Making use of Nimodipine and cerebrolysin earlier can improve the prognosis of neonate with HIE markedly.