Avascular necrosis--an antineoplastic-treatment-related toxicity: the experiences of two institutions |
| |
Authors: | Sawicka-Zukowska Małgorzata Kajdas Lidia Muszynska-Roslan Katarzyna Krawczuk-Rybak Maryna Sonta-Jakimczyk Danuta Szczepanski Tomasz |
| |
Institution: |
a Department of Paediatric Oncology, Medical University, Bialystok, Poland
b Department of Pediatric Hematology and Oncology, Silesian Medical Academy, Zabrze, Poland |
| |
Abstract: | Avascular necrosis (avn) is a complication of treatment for malignancies in children and adolescents. The authors present a two-center retrospective of experiences with avn in children treated for acute lymphoblastic leukaemia or non-Hodgkin lymphoma (8 from 191 patients with newly diagnosed disease in total of 19 sites). The median age at diagnosis was 16.6 years. Avn was observed in 4.1% of the group, higher among males than females (7/1), both during and after therapy. Early diagnosis of the process has enabled 7 patients to avoid surgical intervention. The increased incidence of avn, the multimodal character of symptoms, but unknown late consequences of avn showed that prospective studies of early recognition and proper therapy are needed. |
| |
Keywords: | avascular necrosis osteonecrosis chemotherapy steroids children |
本文献已被 InformaWorld PubMed 等数据库收录! |
|