| 阻塞性黄疸大鼠离体胸主动脉收缩与舒张功能的变化 |
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| 引用本文： | 吴刚,徐学武,缪雪荣,杨立群,李泉,俞卫锋. 阻塞性黄疸大鼠离体胸主动脉收缩与舒张功能的变化[J]. 第二军医大学学报, 2009, 30(2): 162-165. DOI: 10.3724/SP.J.1008.2009.00162 |
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| 作者姓名： | 吴刚 徐学武 缪雪荣 杨立群 李泉 俞卫锋 |
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| 作者单位： | 第二军医大学东方肝胆外科医院麻醉科,上海,200438 |
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| 基金项目： | 国家自然科学基金(30600584). |
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| 摘 要： | 目的:研究阻塞性黄疸大鼠离体胸主动脉收缩及舒张功能的变化规律,探讨高胆红素血症导致阻塞性黄疸大鼠离体胸主动脉收缩及舒张功能变化的可能机制。方法:60只雄性SD大鼠随机分为胆总管结扎(BDL)组和假手术(SO)组,每组30只,术后3、7、14 d,取大鼠离体胸主动脉环,分别测定大鼠胸主动脉对高浓度钾离子(K+)诱发的最大收缩幅度、梯度浓度去甲肾上腺素(NE)和去氧肾上腺素(PE)引起的收缩反应以及硝普钠(SNP)引起的舒张反应。另取40只雄性SD大鼠,随机分为SO组、BDL 3 d组、BDL 7 d组、BDL 14 d组,每组10只。取大鼠的胸主动脉组织,利用Western印迹方法检测大鼠胸主动脉肾上腺素α1D受体亚型(α1D-AR)蛋白表达情况。结果:高钾离子、NE、PE 在BDL大鼠离体胸主动脉引起的收缩反应弱于SO组,而硝普钠引起的舒张反应强于SO组；BDL组大鼠α1D-AR蛋白表达较SO组减弱,并且随阻塞时间的延长,减弱更加明显。结论:BDL大鼠离体胸主动脉的收缩与舒张功能在高胆红素血症时发生改变,α1D-AR蛋白表达下降可能是收缩功能减弱的原因之一。
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| 关 键 词： | 阻塞性黄疸 胸主动脉 血管收缩 血管舒张 |
| 收稿时间： | 2008-05-09 |
| 修稿时间： | 2008-11-06 |
Changes of vasoconstrictor and vasodilator functions of isolated thoracic aorta rings in rats with obstructive jaundice |
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| WU Gang,XU Xue-wu,MIAO Xue-rong,YANG Li-qun,LI Quan,YU Wei-feng. Changes of vasoconstrictor and vasodilator functions of isolated thoracic aorta rings in rats with obstructive jaundice[J]. Former Academic Journal of Second Military Medical University, 2009, 30(2): 162-165. DOI: 10.3724/SP.J.1008.2009.00162 |
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| Authors: | WU Gang XU Xue-wu MIAO Xue-rong YANG Li-qun LI Quan YU Wei-feng |
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| Affiliation: | Department of Anesthesiology,Eastern Hepatobiliary Hospital,Second Military Medical University,Shanghai 200438,China |
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| Abstract: | Objective:To investigate the changes of vasoconstrictor and vasodilator functions of isolated thoracic aorta in the rats with obstructive jaundice,so as to study the mechanism for the functional changes of the aorta in rats with obstructive jaundice.Methods:Sixty male SD rats were randomly divided into bile duct ligation (BDL) group and sham operation (SO) group.The thoracic aortas were isolated at 3,7 and 14 d after surgery and the vasoconstrictor responses induced by high potassium,norepinephrine (NE) and... |
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| Keywords: | obstructive jaundice thoracic aorta vasoconstriction vasodilation |
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