Bacteria involved in the blockage of biliary stents and their susceptibility to antibacterial agents |
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| Authors: | G. Molinari V. Pugliese G. C. Schito C. A. Guzmán |
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| Affiliation: | (1) Institute of Microbiology, University of Genoa, Viale Benedetto XV, 10, 16132 Genoa, Italy;(2) Department of Endoscopy and Gastroenterology, I.S.T. National Institute for Cancer Research, Viale Benedetto XV, 10, 16132 Genoa, Italy;(3) Division of Microbiology, GBF-National Research Centre for Biotechnology, Mascheroder Weg 1, 38124 Braunschweig, Germany |
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| Abstract: | Endoscopically inserted stents are used for the palliation of obstructive jaundice, but infections and blockage of these stents by biliary sludge and bacterial biofilm may develop, presenting major complications. To analyze which bacteria are involved in this process, 25 biliary stents were examined. Eighty-one microorganisms were isolated: 59 gram-negative bacteria (54Enterobacteriaceae and 5Pseudomonas aeruginosa), 19 gram-positive bacteria (allEnterococcus spp.), and 3Candida albicans. TheEnterobacteriaceae were sensitive to netilmicin (100%), imipenem (98%), ciprofloxacin (96%), cefotaxime (69%), and piperacillin (57%), whereasEnterococcus spp. were sensitive to imipenem (79%), piperacillin (75%), ciprofloxacin (63%), and ampicillin (58%). The unpredictable aetiology and high rates of antibiotic resistance suggest that bacteriological monitoring is mandatory to avoid treatment failures in these patients. |
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