内皮祖细胞治疗缺血性脑血管病的研究进展

内皮祖细胞（endothelial progenitor cell，EPC）可促进缺血损伤后脑组织血管新生及神经发生。近年来，移植外源性EPC、动员内源性EPC等治疗方法在缺血性脑血管病的实验研究中开辟了新的途径，并证实EPC在外周血中的水平对缺血性脑血管病的严重性及预后具有预测价值。本文对EPC治疗缺血性脑血管病的作用机制，治疗策略，在临床应用中尚存在的问题，以及最新研究进展做一综述。

Advances in the Treatment of Endothelial Progenitor Cell in Ischemic Cerebrovascular Disease

Endothelial progenitor cell (EPC) can promote the angiogenesis and the neurogenesis in the cerebral ischemic injury. In recent years, the therapeutic strategy such as transplanting EPC or mobilizing EPC opens a new avenue in the experimental research, and it has demonstrated that the level of EPC in the peripheral blood has a predictive value in the severity and prognosis of ischemic cerebrovascular disease. In this article, we make a review of the mechanism of EPC in the treatment, the therapeutic strategy, the existing problems in the clinical application, as well as the advances in the latest research.