小胶质细胞激活介导非特异性炎症在血管性认知障碍白质脱髓鞘损伤机制中的研究进展

小胶质细胞作为中枢神经系统免疫监视的主要细胞， 在脑组织急慢性缺血性损伤中可通过介导炎症及氧化应激反应释放多种具有神经毒性的产物， 进一步引起神经元和其他胶质细胞的死亡。 血管性认知障碍作为脑组织慢性缺血性损伤导致的一种以磁共振成像下脑白质脱髓鞘为特征的疾病， 缺血性非特异炎症在其白质损伤中的作用机制愈发得到重视。 本文对有关脑组织缺血引起小胶质细胞激活所介导非特异性炎症进而造成脑白质脱髓鞘损伤的机制相关研究做一综述， 以期能够为进一步的相关机制研究提供参考和帮助。

Progress of Researches on the Mechanism of the Role of Nonspecific InflammationMediatedby Microglia Activation in the White Matter Demyelination of VascularCognitive Impairment

Microglia as the main immune surveillance cell in central nervous system can cause acute or chroniccerebral ischemic injury via mediating inflammation and oxidative stress and releasing varietiesof products with neurotoxicity, which could even cause the death of neurons and other glial cells.White matter demyelinatingis the feature of vascular cognitive impairment, marked by magneticresonance imaging of brain, which is a disease caused by chronic cerebral ischemic damage. Wereviewed researches on the mechanism of the role of ischemic nonspecific inflammation in thewhite matter damage mediated by microglia activation, in order to provide reference and help forfurther mechanism studies.