Wirkung der Lipoxygenase- und Cyclooxygenase-Metaboliten auf die akute hypoxische pulmonale Vasokonstriktion beim Schweinchen

The role of lipoxygenase and cyclooxygeriase metabolites in acute hypoxic pulmonary vasoconstriction (HPV) was studied in piglets, it has been found that acute alveolar hypoxia induced remarkable pulmonary vasoconstrion, associated with an increase in cardiac output. The hypoxic pulmonary vasoconstriction response was insignificantly attenuated after infusion of DEC. indomethacin potentiated mar kedly the increase in pulmonary artery pressure and pulmonary vascular resistance and thus augmented HPV. It is inferred that hypoxic pulmonary vsaoconstriction in piglet may be mediated by other important mediators in addition to leukotrienes, but modulated by prostaglandins to prevent an excessive rise in pulmonary artery pressure.