Effect of blood loss on nitric oxide content in liver and mucosa and muscle layer of small intestine in rats |
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| Authors: | K. S. Koval'skaya P. I. Mordvintsev A. F. Vanin |
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| Affiliation: | (1) Laboratory of Experimental Pathology, N. V. Sklifosofskii Institute for Energency Medicine, Moscow;(2) Laboratory of Physical Chemistry of Biopolimer, Institute of Chemical Physics, Russian Academy of Sciences, Moscow |
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| Abstract: | Moderate blood loss (20 ml/kg) increases NO content in the intestinal mucosa and muscle layer, and especially, in the liver, as revealed byin vivo nitric oxide (NO) binding with Fe2+-diethyldithiocarbamate complex yielding paramagnetic mononitrosyl iron complexes. Enhanced NO synthesis after blood loss prevents vascular spasm in the mucosa, thus maintaining blood circulation and effective absorption in the small intestine. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 8, pp. 153–156, August, 1999 |
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| Keywords: | absorption small intestine nitric oxide blood loss |
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