Successful resection of dermatomyositis associated with thymic carcinoma: Report of a case |
| |
| Authors: | Fumiyuki Takahashi Koji Tsuta Tetsutaro Nagaoka Hideaki Miyamoto Yuichi Saito Hirofumi Amano Koji Uchida Yoshiteru Morio Kazue Shimizu Shinichi Sasaki Shigeru Tominaga Toshimasa Uekusa Hiroshi Izumi Yoichi Anami Yoshihiro Matsuno Kazuhisa Takahashi Yoshinosuke Fukuchi |
| |
| Affiliation: | (1) Departments of Respiratory Medicine, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan;(2) Departments of General Thoracic Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan;(3) Departments of Rheumatology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan;(4) Departments of Pathology I, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan;(5) Department of Pathology, National Cancer Center Research Institute and Hospital, Tokyo, Japan;(6) Department of Laboratory Medicine, Kanto Rousai Hospital, Kawasaki, Kanagawa, Japan |
| |
| Abstract: | We report a case of thymic carcinoma associated with dermatomyositis (DM) in a 53-year-old man. The patient presented with the characteristic features of a skin rash with Gottron’s papules, proximal muscle weakness, and increased serum levels of the muscle-associated enzymes. Comprehensive clinical examinations revealed an anterior mediastinal tumor. We resected the tumor and histological examination confirmed squamous cell carcinoma of the thymus. Thereafter, his clinical symptoms improved dramatically and his serum levels of muscleassociated enzymes dropped, indicating that the DM was a paraneoplastic phenomenon. Our search of the literature found only one other case report of DM accompanied by thymic carcinoma, and to our knowledge, this is the fi rst documented case of dramatic improvement of DM after resection of thymic carcinoma. We propose that thymic carcinoma should be added to the list of malignancies that can complicate DM as a paraneoplastic disease. The first two authors contributed equally to this study. |
| |
| Keywords: | Thymic carcinoma Dermatomyositis Surgical resection |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
