乳腺良恶性病变核仁组成区形态定量研究

使用胶质银染对61例乳腺病变组织石蜡切片进行了核仁组成区(AgNOR)定量研究。乳腺腺病10例、腺瘤11例、管内乳头状瘤13例,导管内癌10例,导管浸润癌10例,髓样癌7例。观察结果表明,乳腺良性肿瘤和恶性病变之间,平均每核AgNOR颗粒数相差非常显著(P<0.01)。腺瘤与管内乳头状瘤之间,以及导管内癌与导管浸润癌之间,AgNOR颗粒数亦有明显差异。本文结果提示:AgNOR定量观察不仅有助于乳腺良恶性病变的鉴别,对乳腺肿瘤分类亦有一定的帮助。

Quantitative study of AgNORs in benign and malignant lesions of breast

Using silver colloid staining techique, the nucleo lar organizer region-associated proteins ( AgNORs ) can be stained and studied by means of quantitative methods in paraffin sections of 61 breast tumors, including 10 adenosis, 11 adenomas, 13 intraductal papillomas, 10 intraductal carcinomas, 10 ductal invasive carcinomas, and 7 medullary carcinomas. The results showed that there were significant differences in the mean number of AgNORs per nucleus among adenosis and benign and malignant tumors(P<0.01).It was also found that significant differences existed between adenoma and papilloma, and between intradutal carcinoma and infiltrating ductal carcinoma. It is suggested that this simple technique may be heloful in differentiating benign and malignant breast tumors and in the grading of tumors.