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| 可植入微型轴流血泵溶血实验研究 | |
| 引用本文： | 王玉璇,张杰民,施超,刘晓程. 可植入微型轴流血泵溶血实验研究[J]. 山西医科大学学报, 2010, 41(2): 133-136 |
| 作者姓名： | 王玉璇 张杰民 施超 刘晓程 |
| 作者单位： | 1. 中国医学科学院,北京协和医学院,北京100730 2. 泰达国际心血管病医院辅助循环研究室 3. 中国医学科学院,北京协和医学院,北京100730;泰达国际心血管病医院辅助循环研究室 |
| 基金项目： | 天津市科技支撑计划重点项目 |
| 摘 要： | 目的通过自制轴流血泵进行体外、体内溶血实验，探讨血泵的溶血特性。方法轴流血泵置于充满新鲜羊血的模拟循环通路中，在输出流量为5L／min，后负荷压力为100mmHg的条件下，检测血泵体外溶血水平。在3只健康绵羊体内植入血泵进行在体辅助实验，并稳定运转24h，测定其在体溶血水平。结果可植入微型轴流血泵的体外溶血指数（normal index of haematolysis，NIH）为（0．01644±0．00018）g／100L。在体实验中，血泵运行无机械故障，循环辅助后血浆游离血红蛋白（plasma free hemoglobin，FHb）及乳酸脱氢酶（lactate dehydrogenase，LDH）呈现上升趋势，平均最大值分别达（7．93±0．71）g／L、（622．3±22．5）U／L。结论血泵溶血性能在可接受范围内，接近于部分国外三代血泵溶血水平，初步具备进入动物辅助实验研究水平。 |
| 关 键 词： | 心室辅助装置 轴流血泵 溶血实验 |
Hemolysis test about a self-made miniature implantable axial flow blood pump in vitro and in vivo |
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| WANG Yu-xuan,ZHANG Jie-min,SHI Chao,LIU Xiao-cheng. Hemolysis test about a self-made miniature implantable axial flow blood pump in vitro and in vivo[J]. Journal of Shanxi Medical University, 2010, 41(2): 133-136 | |
| Authors: | WANG Yu-xuan ZHANG Jie-min SHI Chao LIU Xiao-cheng |
| Affiliation: | WANG Yu-xuan1,ZHANG Jie-min2,SHI Chao1,LIU Xiao-cheng1,2 (1Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100730,China,2Laboratory of Mechanical Circulatory Support,TEDA International Cardiovascular Hospital) |
| Abstract: | Objective To explore the hemolytic characteristics of a self-made implantable axial flow blood pump in vitro and in vivo. Methods Blood pumps were connected with the pump in a mock circulatory loop,filled with fresh sheep blood,and the pump generated 5 L/min flow against a head pressure of 100 mmHg.The vitro hemolytic properties were evaluated by determining the level of plasma free hemoglobin(FHb)at defined intervals.Blood pump was implanted in 3 healthy sheep for in vivo test.After pumping,FHb,lactate deh... |
| Keywords: | ventricular assist devices miniature axial blood pump hemolysis test |
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