| 海带多糖排铅作用研究 |
| |
| 引用本文： | 王园园,于一,倪倍倍,王蜀平,石振艳,岳旺.海带多糖排铅作用研究[J].泰山医学院学报,2010,31(6):440-442. |
| |
| 作者姓名： | 王园园 于一 倪倍倍 王蜀平 石振艳 岳旺 |
| |
| 作者单位： | 青岛大学医学院药理学教研室,山东,青岛,266021 |
| |
| 摘 要： | 目的在大鼠铅中毒模型,研究海带多糖排铅作用。方法将雌雄各半48只大鼠,随机分正常对照组（正常饮食30天）、模型组（自由饮用0.3%醋酸铅水溶液30 d）、青霉胺组（自由饮用0.3%醋酸铅水溶液30d＋按90 mg.kg-1体重ip青霉胺21 d）、海带多糖低、中、高剂量组（自由饮用0.3%醋酸铅水溶液30d＋50 mg.kg-1、100mg.kg-1、200 mg.kg-1ig海带多糖）。实验结束处死大鼠,测定血铅、网织红细胞百分比、血清标志酶活性。结果海带多糖能降低铅中毒后的血铅;减少网织红细胞数目（P〈0.05）;改善乳酸脱氢酶（LDH）活性（P〈0.05）,升高葡萄糖-6-磷酸脱氢酶（G-6-PD）和酸性磷酸酶（ACP）活性（P〈0.05）。结论海带多糖对铅中毒大鼠有排铅作用。
|
| 关 键 词： | 海带多糖 排铅 铅中毒 |
Effects of alginate on rats with lead poisoning |
| |
| WANG yuan-yuan,YU yi,NI beibei,WANG shu-ping,SHI zhen-yan,YUE wang.Effects of alginate on rats with lead poisoning[J].Journal of Taishan Medical College,2010,31(6):440-442. |
| |
| Authors: | WANG yuan-yuan YU yi NI beibei WANG shu-ping SHI zhen-yan YUE wang |
| |
| Institution: | WANG yuan-yuan YU yi NI beibei WANG shu-ping SHI zhen-yan YUE wang(Dept.of Pharmacology,Qingdao Med Univ,Qingdao 266021,China) |
| |
| Abstract: | Objective：To study the effect of alginate on the lead poisoning rats.Methods：（1） normal control group,After 1 week＇s exposure to lead,the rats were randomly divided into 5 groups：（2） model group（0.3%Pb（AC）2）（3）Penicillamine group（90 mg·kg-1）,（4）high-dose alginate group（200 mg·kg-1）,（5）middle-dose alginate group（100 mg·kg-1）,（6）low-dose alginate group（50 mg·kg-1）.After 1 month treatment,blood lead,reticulocyte percentage,serum marker enzyme activity were measured.Results： Alginate can lower the blood lead,reticulocyte,and improve G-6-PD,ACP levels.Conclusion： The alginate has a protective effect on rats with lead poisoning,and is expected to develop into a low toxicity of lead poisoning in the protection of natural medicine. |
| |
| Keywords: | alginate excretion lead poisoning |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
