肺癌与慢性阻塞性肺疾病患者肺炎衣原体感染状况分析

目的探讨肺癌和慢性阻塞性肺疾病(COPD)患者中肺炎衣原体(Cpn)的感染状况.方法应用固相酶联免疫吸附法,对确诊的128例肺癌和126例COPD急性加重期患者进行血清肺炎衣原体抗体IgM,IgG检测,以70例健康人为正常对照组(简称对照组).结果COPD组肺炎衣原体IgM抗体阳性率(36.5%,46/126)及IgM和/或IgG阳性率(32.8%,42/126),均较肺癌组(分别为21.8%,28/128和23.1%,30/128)及对照组(分别为1.4%,1/70和2.8%,2/70)明显升高(P＜0.005),肺癌组IgM阳性率较对照组明显升高(P＜0.005)IgM和/或IgG阳性人数为74例,总感染率为22.8%(74/324).结论肺癌和COPD患者都是Cpn易感染人群,其Cpn感染主要表现为急性感染.Cpn可能是COPD急性加重和肺癌合并肺部感染的主要病原.

Chlamydia pneumoniae infection in patients with lung cancer and chronic obstructive pulmonary disease

Objective:To investigate the presence of chlamydia pneumoniae(Cpn)infection in patients with acute exacerbation of chronic obstructive pulmonary disease(COPD)and lung cancer.Methods:Serum IgM and IgG antibodies for Chlamydia pneumoniae in patients,in which126and128cases were COPD and lung cancer group respectively,were measured by enzyme-linked immunosorbant assays.The70samples of the healthy control group were selected from the healthy outpatients during physical examinations.Results:The positive ratio of serologic IgM antibodies for Cpn in group COPD was up to36.5%(46/126)which was much higher than that in group lung cancer(21.8%,28/128)and that in the control(1.4%,1/70).The differ-ence was statistically significant(P<0.005),respectively.And the ratio of group lung cancer was the same statistically significant difference(P<0.005).While the positive ratio of serologic IgG antibodies in either group COPD or group lung cancer was no statistical significance,compared with the control.But the positive ratio of IgM and/or IgG antibodies of group COPD and group lung cancer were32.8%(42/126)and23.1%(30/128),respectively.which had the significant differences,compared with the control.And the total-positive ratio of all the samples reached22.8%(74/324).Conclusion:It shows that patients with lung cancer accom-panied by pulmonary infection and acute exacerbation of chronic obstructive pulmonary disease are all liable to the infection of chlamydia pneumoniae,of which the clinical presentation is acute infection.And Cpn may be the main pathogenic microbes of those patients and so Cpn infection should be considered for patientswith lung cancer companied with pulmonary infection and acute exacerbation of COPD.