Novel method for rapid, simultaneous T1, T*2, and proton density quantification. |
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| Authors: | J B M Warntjes O Dahlqvist P Lundberg |
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| Affiliation: | 1. Center for Medical Image Science and Visualization, Link?ping University, Link?ping, Sweden;2. Division of Clinical Physiology, Department of Medicine and Care, Link?ping University, Link?ping, Sweden;3. www.cmiv.liu.seCenter for Medical Imaging and Visualization, CMIV, Link?ping University, SE 58185 Link?ping, Sweden===;4. Division of Radiation Physics, Department of Medicine and Care, Link?ping University, Link?ping, Sweden;5. Department of Radiation Physics, University Hospital of Link?ping, Link?ping, Sweden |
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| Abstract: | An imaging method called "quantification of relaxation times and proton density by twin-echo saturation-recovery turbo-field echo" (QRAPTEST) is presented as a means of quickly determining the longitudinal T(1) and transverse T(2) (*) relaxation time and proton density (PD) within a single sequence. The method also includes an estimation of the B(1) field inhomogeneity. High-resolution images covering large volumes can be achieved within clinically acceptable times of 5-10 min. The range of accuracy for determining T(1), T(2) (*), and PD values is flexible and can be optimized relative to any anticipated values. We validated the experimental results against existing methods, and provide a clinical example in which quantification of the whole brain using 1.5 mm(3) voxels was achieved in less than 8 min. |
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| Keywords: | T1 mapping T mapping proton density mapping quantitative MRI rapid quantification |
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